Effect of trace amine-associated receptor 1 agonist RO5263397 on sensory gating in mice.
Neuroreport
; 30(15): 1004-1007, 2019 10 16.
Article
in En
| MEDLINE
| ID: mdl-31503202
ABSTRACT
The trace amine-associated receptor 1 (TAAR1) agonist RO5263397 effect on sensory gating in C57BL/6 mice was studied. Sensory gating is a mechanism for dosing and filtering the incoming information, by which the brain regulates the responses to sensory stimuli coming from the environment. Sensory gating deficit is considered to be one of the schizophrenia endophenotypes. TAAR1 agonist at a 1 mg/kg dosage contributed to the sensory gating index (S1-S2) increase. Sensory gating index rose due to the N40 amplitude increase in response to the first stimulus in a pair, whereas the amplitude of the second stimulus remained unchanged. These results suggest that the sensory gating in mice may be modulated through TAAR1-dependent processes, indicating potential contribution of TAAR1 and trace amines in general to the neuropharmacology of cognitive processes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxazoles
/
Schizophrenia
/
Antipsychotic Agents
/
Receptors, G-Protein-Coupled
/
Sensory Gating
Type of study:
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
Neuroreport
Journal subject:
NEUROLOGIA
Year:
2019
Document type:
Article
Affiliation country: